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KMID : 0604519980240030134
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Journal of the Society of Cosmetic Scientists of Korea
1998 Volume.24 No. 3 p.134 ~ p.145
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BQ-788 (ENDOTHELIN-B RECEPTOR ANTAGONIST) BLOCKS KERATINOCYTE-INDUCED DENDRICITY 01 CULTURED IHELANOCYTES
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Cho Joon-Hwan
Lee Ki-Moo
Kim Nam-Soo
Sohn Seong-Hyang
Kang Won-Hyoung
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Abstract
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Facial hyperpigmentation in women, which is considered to be a serious cosmetic disability and a cause of mental distress, requires proper management. Melanocyte dendricity is a crucial factor affecting epidermal pigmentation. We found that BQ-788, the endothelin-B (ETB) receptor antagonist, blocks the formation of multi-dendricity which is induced by cocultured keratinocytes. Melanocytes in vivo show numerous dendrites which are in close contact with multiple keratinocytes, forming the epidermal-melanin unit. While melanocytes transfer their melanosomes into the neighboring keratinocytes via dendrites, keratinocytes secrete many growth factors and cytokines that influence viability, morphology, and melanin formation of melanocytes. Endothelin-1 (ET-1), prostaglandin E2(PGE2), and leukotriene-C4 (LT-C4) have been suggested as the candidates for increasing dendricity. Other reports suggested that ET-1 has stimulatory effects on proliferation and melanin formation of melanocytes in vitro. In the present study, using type-specific ET receptor antagonists, we observed how the morphology of melanocytes could be modulated in a coculture system. In addition, the roles of ET-1 for morphology and proliferation on melanocytes were evaluated in different culture media. We suggest that ET-1 increases dendricity and proliferation of melanocytes, and that its dendrite-inducing effect and mitogenic effect are regulated independently.
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KEYWORD
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Endothelin-1, endothelin-B receptor antagonist(BQ-788), keratinocytes, melanocytes, dendricity
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